Prednisone (a corticosteroid medication) and long-term supraphysiologic levels of corticosteroids can cause weight gain and fat redistribution [1, 2]. Cushing Syndrome and adrenal cancers also seem to cause significant weight gain . Whereas, short-term corticosteroid use for something like asthma does not look to cause weight gain . However, if these medications are taken for longer durations there may be something there .
Therefore, whenever possible, it is likely best to avoid getting hit with high doses of exogenous corticosteroids. Also…
“Corticosteroids are commonly used as anti-inflammatory agents in injured athletes. In these athletes, adrenal insufficiency is observed for up to 14 days in response to a single intra- or periarticular injections of corticosteroids.”-Duclos et al. 2016 
Persistent and inescapable chronic stress, especially in early life, has also been consistently linked to obesity, as well as, increased risk of physical and mental disease [7-10].
But, do physiologic elevations or fluctuations in cortisol correlate or independently cause body composition changes?
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